| 1 | CINCincinnatiFC CincinnatiShield | 34 | 20 | 5 | 9 | 57 | 39 | +18 | 69 | 2.03 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 2 | ORLOrlandoOrlando City SC | 34 | 18 | 7 | 9 | 55 | 39 | +16 | 63 | 1.85 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 3 | CLBColumbusColumbus CrewMLS Cup | 34 | 16 | 9 | 9 | 67 | 46 | +21 | 57 | 1.68 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 4 | STLSt. LouisSt. Louis City SC | 34 | 17 | 12 | 5 | 62 | 45 | +17 | 56 | 1.65 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 5 | PHIPhiladelphiaPhiladelphia Union | 34 | 15 | 9 | 10 | 57 | 41 | +16 | 55 | 1.62 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 6 | NENew EnglandNew England Revolution | 34 | 15 | 9 | 10 | 58 | 46 | +12 | 55 | 1.62 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 7 | SEASeattleSeattle Sounders FC | 34 | 14 | 9 | 11 | 41 | 32 | +9 | 53 | 1.56 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 8 | LAFCLAFCLos Angeles FCFinalist | 34 | 14 | 10 | 10 | 54 | 39 | +15 | 52 | 1.53 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 9 | HOUHoustonHouston Dynamo FC | 34 | 14 | 11 | 9 | 51 | 38 | +13 | 51 | 1.50 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 10 | ATLAtlantaAtlanta United FC | 34 | 13 | 9 | 12 | 66 | 53 | +13 | 51 | 1.50 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 11 | RSLSalt LakeReal Salt Lake | 34 | 14 | 12 | 8 | 48 | 50 | −2 | 50 | 1.47 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 12 | NSHNashvilleNashville SC | 34 | 13 | 11 | 10 | 39 | 32 | +7 | 49 | 1.44 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 13 | VANVancouverVancouver Whitecaps FC | 34 | 12 | 10 | 12 | 55 | 48 | +7 | 48 | 1.41 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 14 | DALDallasFC Dallas | 34 | 11 | 10 | 13 | 41 | 37 | +4 | 46 | 1.35 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 15 | SKCSporting KCSporting Kansas City | 34 | 12 | 14 | 8 | 48 | 51 | −3 | 44 | 1.29 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 16 | SJSan JoseSan Jose Earthquakes | 34 | 10 | 10 | 14 | 39 | 43 | −4 | 44 | 1.29 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 17 | RBNYRed BullsNew York Red Bulls | 34 | 11 | 13 | 10 | 36 | 39 | −3 | 43 | 1.26 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 18 | PORPortlandPortland Timbers | 34 | 11 | 13 | 10 | 46 | 58 | −12 | 43 | 1.26 | |
| 19 | CLTCharlotteCharlotte FC | 34 | 10 | 11 | 13 | 45 | 52 | −7 | 43 | 1.26 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 20 | MTLMontréalCF Montréal | 34 | 12 | 17 | 5 | 36 | 52 | −16 | 41 | 1.21 | |
| 21 | MINMinnesotaMinnesota United FC | 34 | 10 | 13 | 11 | 46 | 51 | −5 | 41 | 1.21 | |
| 22 | NYCNYCFCNew York City FC | 34 | 9 | 11 | 14 | 35 | 39 | −4 | 41 | 1.21 | |
| 23 | DCD.C.D.C. United | 34 | 10 | 14 | 10 | 45 | 49 | −4 | 40 | 1.18 | |
| 24 | CHIChicagoChicago Fire FC | 34 | 10 | 14 | 10 | 39 | 51 | −12 | 40 | 1.18 | |
| 25 | ATXAustinAustin FC | 34 | 10 | 15 | 9 | 49 | 55 | −6 | 39 | 1.15 | |
| 26 | LALA GalaxyLA Galaxy | 34 | 8 | 14 | 12 | 51 | 67 | −16 | 36 | 1.06 | |
| 27 | MIAMiamiInter Miami CF | 34 | 9 | 18 | 7 | 41 | 54 | −13 | 34 | 1.00 | |
| 28 | COLColoradoColorado Rapids | 34 | 5 | 17 | 12 | 26 | 54 | −28 | 27 | 0.79 | |
| 29 | TORTorontoToronto FCSpoon | 34 | 4 | 20 | 10 | 26 | 59 | −33 | 22 | 0.65 | |