| 1 | LAFCLAFCLos Angeles FCMLS CupShield | 34 | 21 | 9 | 4 | 66 | 38 | +28 | 67 | 1.97 | Qualifies for MLS Cup playoffs Conference semifinals |
| 2 | PHIPhiladelphiaPhiladelphia UnionFinalist | 34 | 19 | 5 | 10 | 72 | 26 | +46 | 67 | 1.97 | Qualifies for MLS Cup playoffs Conference semifinals |
| 3 | MTLMontréalCF Montréal | 34 | 20 | 9 | 5 | 63 | 50 | +13 | 65 | 1.91 | Qualifies for MLS Cup playoffs round one |
| 4 | ATXAustinAustin FC | 34 | 16 | 10 | 8 | 65 | 49 | +16 | 56 | 1.65 | Qualifies for MLS Cup playoffs round one |
| 5 | NYCNYCFCNew York City FC | 34 | 16 | 11 | 7 | 57 | 41 | +16 | 55 | 1.62 | Qualifies for MLS Cup playoffs round one |
| 6 | RBNYRed BullsNew York Red Bulls | 34 | 15 | 11 | 8 | 50 | 41 | +9 | 53 | 1.56 | Qualifies for MLS Cup playoffs round one |
| 7 | DALDallasFC Dallas | 34 | 14 | 9 | 11 | 48 | 37 | +11 | 53 | 1.56 | Qualifies for MLS Cup playoffs round one |
| 8 | LALA GalaxyLA Galaxy | 34 | 14 | 12 | 8 | 58 | 51 | +7 | 50 | 1.47 | Qualifies for MLS Cup playoffs round one |
| 9 | NSHNashvilleNashville SC | 34 | 13 | 10 | 11 | 52 | 41 | +11 | 50 | 1.47 | Qualifies for MLS Cup playoffs round one |
| 10 | CINCincinnatiFC Cincinnati | 34 | 12 | 9 | 13 | 64 | 56 | +8 | 49 | 1.44 | Qualifies for MLS Cup playoffs round one |
| 11 | MINMinnesotaMinnesota United FC | 34 | 14 | 14 | 6 | 48 | 51 | −3 | 48 | 1.41 | Qualifies for MLS Cup playoffs round one |
| 12 | MIAMiamiInter Miami CF | 34 | 14 | 14 | 6 | 47 | 56 | −9 | 48 | 1.41 | Qualifies for MLS Cup playoffs round one |
| 13 | ORLOrlandoOrlando City SC | 34 | 14 | 14 | 6 | 44 | 53 | −9 | 48 | 1.41 | Qualifies for MLS Cup playoffs round one |
| 14 | RSLSalt LakeReal Salt Lake | 34 | 12 | 11 | 11 | 43 | 45 | −2 | 47 | 1.38 | Qualifies for MLS Cup playoffs round one |
| 15 | PORPortlandPortland Timbers | 34 | 11 | 10 | 13 | 53 | 53 | 0 | 46 | 1.35 | |
| 16 | CLBColumbusColumbus Crew | 34 | 10 | 8 | 16 | 46 | 41 | +5 | 46 | 1.35 | |
| 17 | VANVancouverVancouver Whitecaps FC | 34 | 12 | 15 | 7 | 40 | 57 | −17 | 43 | 1.26 | |
| 18 | COLColoradoColorado Rapids | 34 | 11 | 13 | 10 | 46 | 57 | −11 | 43 | 1.26 | |
| 19 | CLTCharlotteCharlotte FC | 34 | 13 | 18 | 3 | 44 | 52 | −8 | 42 | 1.24 | |
| 20 | NENew EnglandNew England Revolution | 34 | 10 | 12 | 12 | 47 | 50 | −3 | 42 | 1.24 | |
| 21 | SEASeattleSeattle Sounders FC | 34 | 12 | 17 | 5 | 47 | 46 | +1 | 41 | 1.21 | |
| 22 | SKCSporting KCSporting Kansas City | 34 | 11 | 16 | 7 | 42 | 54 | −12 | 40 | 1.18 | |
| 23 | ATLAtlantaAtlanta United FC | 34 | 10 | 14 | 10 | 48 | 54 | −6 | 40 | 1.18 | |
| 24 | CHIChicagoChicago Fire FC | 34 | 10 | 15 | 9 | 39 | 48 | −9 | 39 | 1.15 | |
| 25 | HOUHoustonHouston Dynamo FC | 34 | 10 | 18 | 6 | 43 | 56 | −13 | 36 | 1.06 | |
| 26 | SJSan JoseSan Jose Earthquakes | 34 | 8 | 15 | 11 | 52 | 69 | −17 | 35 | 1.03 | |
| 27 | TORTorontoToronto FC | 34 | 9 | 18 | 7 | 49 | 66 | −17 | 34 | 1.00 | |
| 28 | DCD.C.D.C. UnitedSpoon | 34 | 7 | 21 | 6 | 36 | 71 | −35 | 27 | 0.79 | |