| 1 | NSHNashvilleNashville SC | 23 | 16 | 2 | 5 | 47 | 17 | +30 | 53 | 2.30 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 2 | VANVancouverVancouver Whitecaps FC | 22 | 13 | 5 | 4 | 49 | 21 | +28 | 43 | 1.95 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 3 | MIAMiamiInter Miami CF | 23 | 12 | 4 | 7 | 58 | 43 | +15 | 43 | 1.87 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 4 | HOUHoustonHouston Dynamo FC | 23 | 12 | 7 | 4 | 30 | 26 | +4 | 40 | 1.74 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 5 | CHIChicagoChicago Fire FC | 22 | 11 | 6 | 5 | 43 | 32 | +11 | 38 | 1.73 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 6 | NENew EnglandNew England Revolution | 23 | 11 | 8 | 4 | 37 | 29 | +8 | 37 | 1.61 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 7 | LAFCLAFCLos Angeles FC | 24 | 10 | 7 | 7 | 38 | 24 | +14 | 37 | 1.54 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 8 | DALDallasFC Dallas | 23 | 10 | 6 | 7 | 45 | 40 | +5 | 37 | 1.61 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 9 | STLSt. LouisSt. Louis City SC | 23 | 10 | 6 | 7 | 36 | 31 | +5 | 37 | 1.61 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 10 | CLTCharlotteCharlotte FC | 23 | 10 | 7 | 6 | 40 | 32 | +8 | 36 | 1.57 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 11 | SJSan JoseSan Jose Earthquakes | 23 | 10 | 8 | 5 | 40 | 34 | +6 | 35 | 1.52 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 12 | COLColoradoColorado Rapids | 23 | 10 | 12 | 1 | 31 | 31 | 0 | 31 | 1.35 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 13 | PORPortlandPortland Timbers | 23 | 9 | 10 | 4 | 44 | 43 | +1 | 31 | 1.35 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 14 | CINCincinnatiFC Cincinnati | 22 | 8 | 7 | 7 | 49 | 51 | −2 | 31 | 1.41 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 15 | SDSan DiegoSan Diego FC | 23 | 8 | 9 | 6 | 40 | 34 | +6 | 30 | 1.30 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 16 | RSLSalt LakeReal Salt Lake | 22 | 8 | 9 | 5 | 36 | 35 | +1 | 29 | 1.32 | |
| 17 | NYCNYCFCNew York City FC | 23 | 7 | 8 | 8 | 36 | 31 | +5 | 29 | 1.26 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 18 | MINMinnesotaMinnesota United FC | 23 | 7 | 8 | 8 | 34 | 37 | −3 | 29 | 1.26 | |
| 19 | LALA GalaxyLA Galaxy | 24 | 7 | 9 | 8 | 30 | 36 | −6 | 29 | 1.21 | |
| 20 | ORLOrlandoOrlando City SC | 23 | 8 | 11 | 4 | 38 | 54 | −16 | 28 | 1.22 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 21 | PHIPhiladelphiaPhiladelphia Union | 23 | 7 | 10 | 6 | 36 | 39 | −3 | 27 | 1.17 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 22 | SEASeattleSeattle Sounders FC | 22 | 7 | 9 | 6 | 24 | 29 | −5 | 27 | 1.23 | |
| 23 | RBNYRed BullsNew York Red Bulls | 23 | 7 | 10 | 6 | 32 | 46 | −14 | 27 | 1.17 | |
| 24 | TORTorontoToronto FC | 23 | 5 | 7 | 11 | 36 | 42 | −6 | 26 | 1.13 | |
| 25 | ATXAustinAustin FC | 23 | 6 | 10 | 7 | 29 | 42 | −13 | 25 | 1.09 | |
| 26 | DCD.C.D.C. United | 22 | 5 | 7 | 10 | 28 | 36 | −8 | 25 | 1.14 | |
| 27 | CLBColumbusColumbus Crew | 23 | 6 | 12 | 5 | 34 | 39 | −5 | 23 | 1.00 | |
| 28 | ATLAtlantaAtlanta United FC | 23 | 6 | 13 | 4 | 27 | 40 | −13 | 22 | 0.96 | |
| 29 | MTLMontréalCF Montréal | 23 | 5 | 12 | 6 | 30 | 48 | −18 | 21 | 0.91 | |
| 30 | SKCSporting KCSporting Kansas CityLast · so far | 23 | 4 | 16 | 3 | 23 | 58 | −35 | 15 | 0.65 | |